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Nanoemulsion

Grading
System

Size matters in drug delivery, and a nanoemulsion is the most versatile delivery system the world has ever seen. It's considered the gold standard for food and beverage formulations infused with cannabinoids like delta-9 THC (D9). Le Herbe is happy to introduce the world's first grading system for cannabis nanoemulsions because not all formulations are created equal. This point-based system has been in development for seven years and is the result of an industry-university collaboration. We gathered a wide variety of perspectives, including but not limited to consumers, growers, processors, food scientists, chemists, engineers, and much more. We considered numerous grading factors but ultimately came up with 12 categories as a starting point. Each category is weighted by the individual item, available options, category consideration, formulation consideration, and final product conditions.

We invite you to sit down with your team, go through each category, add up the item points in each of the 12 categories, and double- and triple-check your numbers. If you don't see a check mark or numerical value for an item, then put zero and move on to the next item or category. Cannabis nanoemulsions are classified as Grade A, B, C, D, F, or special grades for a select few. Grade D and F are the lowest quality and may not be safe for human consumption. Version 1.0 is the first iteration and will be fine-tuned until perfected.

Contact us today if you would like to add a category, add an item, exclude an item, change a rating, or want to have a conversation about the world's first nanoemulsion grading system. Share with your friends or colleagues, and let's make better cannabis products together.

Version 2.1

Start Here

Cannabis Source + 5 + 4 + 3 + 2 + 1
Sun-Grown (outdoor)
Hydroponic (indoor)
Biosynthesis (yeast)
Cannabis Extract + 5 + 4 + 3 + 2 + 1
Live Rosin
Isolate
Live Resin
Badder / Batter
Distillate
Extract Analysis + 5 + 4 + 3 + 2 + 1
CoA (full panel)
CoA (potency + microbiology)
CoA (potency only)
Registered Lab (DEA)
Accredited Lab (ISO17025)
Non-Accredited Lab
Purity + 99% 99-95% 95-90% 90-80% 80-70%
Carrier Oil + 5 + 4 + 3 + 2 + 1
LCT + Essential Oil
LCT
LCT + MCT + Essential Oil
LCT + MCT
MCT + Essential Oil
Emulsifiers + 5 + 4 + 3 + 2 + 1
Phospholipids
Saponins
Polysorbates
Esters
Proteins
Processing + 5 + 4 + 3 + 2 + 1
Microfluidics
High-Pressure
Sonication
Rotor-Stator
Combo
Taste the Emulsion + 5 + 4 + 3 + 2 + 1
Flavorless
Umami
Sweet / Sour
Salty
Bitter
Lab Analysis + 5 + 4 + 3 + 2 + 1
DLS
D50, nm < 30 30 - 40 40 - 50 50 - 100 100 - 150
D90, nm < 30 30 - 40 40 - 50 50 - 100 100 - 150
PDI < 0.05 0.05 - 0.10 0.10 - 0.15 0.15 - 0.20 0.20 - 0.25
EE, % + 95 94 - 90 89 - 85 84 - 80 79 - 75
TEM
DL, interface
DL, interface + oil core
DL, oil core
ELS
Zeta Potential, mV (pH 3) ± 40 + ± 39 - 35 ± 34 - 30 ± 29 - 25 ± 24 - 20
Zeta Potential, mV (pH 7) ± 40 + ± 39 - 35 ± 34 - 30 ± 29 - 25 ± 24 - 20
Bio Analysis + 5 + 4 + 3 + 2 + 1
In Vitro
In Silico
In Vivo (humans)
In Vivo (animals)
In Vitro + In Vivo
In Silico + In Vivo
Bioaccessibility, % (vitro/silico) + 85 84 - 75 74 - 65 64 - 55 54 - 49
Bioavailability, % (vivo) + 85 84 - 75 74 - 65 64 - 55 54 - 49
Packaging + 5 + 4 + 3 + 2 + 1
Stick Pack / Sachet (powder)
Aluminum Can
Plastic Bottle (opaque)
Plastic Bottle (translucent)
Plastic Bottle (transparent)
Glass Bottle (opaque)
Glass Bottle (translucent)
Glass Bottle (transparent)
Tincture (w dropper)
Filling + 5 + 4 + 3 + 2 + 1
Filling (automated)
Filling (semi-automated)
Filling (hand filled)
Headspace (LN2)
Headspace (CO2)
Headspace (O2)
Storage + 5 + 4 + 3 + 2 + 1
Inside / Dark (< 50° F)
Inside / Dark (50 - 60° F)
Inside / Dark (60 - 75° F)
Inside / Light (< 50° F)
Inside / Light (50 - 60° F)
Inside / Light (60 - 75° F)

FAQs