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Nanoemulsion

Grading
System

Size matters in drug delivery, and a nanoemulsion is the most versatile delivery system the world has ever seen. A nanoemulsion is how you make THC water-soluble, and we're happy to introduce the world's first grading system because not all cannabis beverages are created equal. This point-based system has been in development for ten years and is the result of an industry-university collaboration. We gathered a wide variety of perspectives, including but not limited to consumers, growers, processors, food scientists, chemists, engineers, and much more. We considered numerous grading factors, but focused on 24 categories as a starting point. Each category below is weighted by the individual item, available options, category consideration, formulation consideration, and final product conditions.

We invite you to sit down with your team and go through each category. If you don't see a check mark or numerical value for an item, then put zero and move on to the next category. The online grading system will automatically calculate your score when you select the radio button on the left-hand side of the item, but you can only select one per category. The point total is located above the FAQs, so you can cross-reference the grading scale. Nanoemulsions infused with cannabinoids like THC are classified as Grade A, B, C, D, F, or special grades for a select few. Grades C, D, and F are the lowest quality and may not be safe for human consumption. Version 1.0 is the first iteration and will be fine-tuned until perfected.

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Version 4.5 (April 16, 2024)
I. Cannabis Source 5 4 3 2 1 0
a. Sun-Grown (outdoor)
b. Hydroponic (indoor)
c. Organic Synthesis
d. Biosynthesis
e. Unknown
II. Cannabis Extract 5 4 3 2 1 0
a. Live Rosin
b. Isolate / Crystalline
c. Live Resin
d. Badder / Batter
e. Distillate
III. Lab Type 5 4 3 2 1 0
a. Registered (DEA)
b. Accredited
c. Non-Accredited
IV. Extract Analysis 5 4 3 2 1 0
a. Potency, Microbiology, Pesticides, Solvents, Metals, Mycotoxins, Endotoxins
b. Potency, Microbiology, Pesticides, Solvents, Metals, Mycotoxins
c. Potency, Microbiology, Pesticides, Solvents, Metals
d. Potency, Microbiology, Pesticides, Solvents
e. Potency, Microbiology, Pesticides
V. Extract Purity 5 4 3 2 1 0
a. + 99, %
b. 98–95, %
c. 94–90, %
d. 89–85, %
e. 84–80, %
VI. Carrier Oil 5 4 3 2 1 0
a. LCT + Terpenes
b. LCT
c. LCT + MCT + Terpenes
d. LCT + MCT
e. MCT + Terpenes
VII. Emulsifiers 5 4 3 2 1 0
a. Phospholipids
b. Natural Polysaccharides
c. Polysorbates
d. Saponins
e. Triblock Copolymers
VIII. Processing 5 4 3 2 1 0
a. Spontaneity
b. Microfluidics
c. High-Pressure
d. Sonication
e. Rotor-Stator
IX. EE 5 4 3 2 1 0
a. + 95, %
b. 94–90, %
c. 89–85, %
d. 84–80, %
e. 79–75, %
X. DLS (D50) 5 4 3 2 1 0
a. < 29, nm
b. 30–39, nm
c. 40–49, nm
d. 50–74, nm
e. 75–100, nm
XI. DLS (D90) 5 4 3 2 1 0
a. < 29, nm
b. 30–39, nm
c. 40–49, nm
d. 50–74, nm
e. 75–100, nm
XII. PDI 5 4 3 2 1 0
a. < 0.04
b. 0.05–0.09
c. 0.10–0.14
d. 0.15–0.19
e. 0.20–0.30
XIII. ELS (pH 3) 5 4 3 2 1 0
a. + 50, mV, ±
b. 49–45, mV, ±
c. 44–40, mV, ±
d. 39–35, mV, ±
e. 34–30, mV, ±
XIV. ELS (pH 7) 5 4 3 2 1 0
a. + 50, mV, ±
b. 49–45, mV, ±
c. 44–40, mV, ±
d. 39–35, mV, ±
e. 34–30, mV, ±
XV. DL 5 4 3 2 1 0
a. Core
b. Interface + Core
c. Interface
XVI. PK 5 4 3 2 1 0
a. In Vitro + In Vivo
b. In Silico + In Vivo
c. In Vitro
d. In Silico
e. In Vivo
XVII. Bioavailability 5 4 3 2 1 0
a. + 90, %
b. 89–80, %
c. 79–70, %
d. 69–60, %
e. 59–50, %
XVIII. Taste Modulation 5 4 3 2 1 0
a. Flavorless
b. Umami
c. Sour
d. Sweet
e. Salty
XIX. Preservative 5 4 3 2 1 0
a. None, powder only
c. Combination / Blends
b. Essential Oils
d. Potassium Sorbate
e. Sodium Benzoate
f. Acidulants
XX. Container 5 4 3 2 1 0
a. Mylar, powder only
b. Stainless Steel Keg
c. Glass Bottle, amber or UVAG
d. Glass Bottle, deadleaf or emerald green
e. Glass Bottle, semi-white or white
f. Plastic Bottle, opaque
g. Plastic Bottle, translucent
h. Plastic Bottle, transparent
i. Aluminum Can
XXI. Filling 5 4 3 2 1 0
a. Automated
b. Semi-automated
c. Hand-filled
XXII. Headspace 5 4 3 2 1 0
a. LN2
b. CO2
c. O2
XXIII. Closure 5 4 3 2 1 0
a. None, powder only
c. Cork, synthetic
b. ROPP
d. Bottle Cap, aluminum
e. Can Lid, aluminum
XXIV. Storage 5 4 3 2 1 0
a. 35–44 °F, dark
a. 45–54 °F, dark
b. 55–64 °F, dark
c. 65–74 °F, dark
d. 35–44 °F, light
e. 45–54 °F, light
e. 55–64 °F, light
e. 65–74 °F, light

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